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- W2376471540 abstract "OBJECTIVE: To study the effects of Zileuton on CT-26 murine colon cancer cell and the growth of tumor the mice bearing.METHODS: After CT-26 cells were treated with two concentrations 100 and 200 μmol/L of Zileuton,the morphological changes of CT-26 cells was observed by inverted phase contrast microscope,and the inhibitory rates were assessed by MTT assay.CT-26 transplanted tumor mouse models were established and divided into 3 groups,the control group was received by 100 mg/(kg·d) there distilled water,Zileuton intervention group was received by 100 mg/(kg·d) Zileuton at the beginning,and Zileuton treatment group was received by 100 mg/(kg·d) Zileuton after 14 days of transplantation,10 mice in each group.After 28 days,the growth of tumors and the concentration of CEA in serum were measured,and pathology changes of transplanted tumor tissues in different groups were examined by HE staining.RESULTS:These results of MTT suggestet that Zileuton could decrease the proliferation significantly in a dose-dependent and time-dependent manner in CT-26 cells.And inhibition rates of 100 and 200 μmol/L Zileuton concentration groups in 24,48 and 72 h were 23.44% and 37.92%,33.64% and 63.74%,50.85% and 75.14%,the Zileuton intervention group and the Zileuton treatment group inhibited the tumor volume by(42.3±2.9)% and(20.1±3.9)%,and the tumor weight by(39.0±2.5)% and(24.9±0.6)% respectively.Large tumor necrosis tissue was observed in pathological observation of the intervention group and the treatment group,the intervention group was most obvious.Compared with the control group(142.30±18.83) ng/mL,the CEA of the Zileuton intervention group(72.07±19.90) ng/mL,and the Zileuton treatment group(94.20±21.71) ng/mL were lower(P=0.000).The content of CEA had positive correlation relationship with tumor size and quality(r values were 0.794 and 0.785,P values were both 0.000).CONCLUSION: Zileuton can inhibit colon cancer CT-26 cell proliferation,and inhibit the growth of tumor the mice bearing obviously,and it could achieve better results in the early colon cancer." @default.
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- W2376471540 date "2012-01-01" @default.
- W2376471540 modified "2023-09-23" @default.
- W2376471540 title "Effects of Zileuton on CT-26 murine colon cancer cell and the growth of tumor the mice bearing" @default.
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