Matches in SemOpenAlex for { <https://semopenalex.org/work/W2376472016> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2376472016 abstract "Objective:To observe the curative effect of Tongxie Yaofang on ulcerative colitis(UC),and identify its underlying mechanism.Method:Sixty SPF Wistar rats were randomly divided into the blank group,model group,Tongxie Yaofang low-,moderate-,high-dose groups and sulfasalazine(SASP)group;Except the blank group,the UC models were established by trinitrobenzene sulfonic acid(TNBS)/ethanol enema;after modeling,the Tongxie Yaofang low-,moderate-,high-dose groups were given at dose of 11,22,44 g·kg-1 by gavage)the SASP group was given at dose of 0.3 g·kg-1 by gavage,the blank group and model group were treated with the same volume's physiological saline for 21 days.The morphological injury was observed with the naked eye and scored.Intercellular adhesion molecular-1(ICAM-1)gene and protein expressions were detected by means of RT-PCR and immunohistochemical method.Result:Inflammation and ulceration were found on the colonic mucous membrane of rats in the model group(2.50±1.08),and compared with the blank group(0.08±0.28),P0.05,and the discrepancy was statistically significant,the successful model was proved.The expression amount of ICAM-1 gene and protein of colonic tissues of rats in the model group(0.27±0.05,0.44±0.016 6)was increased than that in the blank group(0.17±0.02,0.32±0.012 3),and the discrepancy was statistically significant(P0.01).Compared with the model group(0.27±0.05,0.44±0.016 6),the expression amount of ICAM-1 in the Tongxie Yaofang high-(0.19±0.03,0.32±0.005 9)and moderate-dose groups(0.20±0.04,0.34±0.010 4)were decreased,and the discrepancy was statistically significant(P0.05,P0.01).Conclusion:The prescription probably decreases the expression amount of ICAM-1 mRNA and ICAM-1 protein,inhibit inflammation cell infiltrate,reduce colon tissue damage,play a role in treatment of UC." @default.
- W2376472016 created "2016-06-24" @default.
- W2376472016 creator A5013852616 @default.
- W2376472016 date "2013-01-01" @default.
- W2376472016 modified "2023-09-26" @default.
- W2376472016 title "Influence of Tongxie Yaofang on the ICAM-1 mRNA and Protein Expression of Colonic Mucosa in Rats with Experimental Ulcerative Colitis" @default.
- W2376472016 hasPublicationYear "2013" @default.
- W2376472016 type Work @default.
- W2376472016 sameAs 2376472016 @default.
- W2376472016 citedByCount "0" @default.
- W2376472016 crossrefType "journal-article" @default.
- W2376472016 hasAuthorship W2376472016A5013852616 @default.
- W2376472016 hasConcept C126322002 @default.
- W2376472016 hasConcept C185592680 @default.
- W2376472016 hasConcept C204232928 @default.
- W2376472016 hasConcept C2775862500 @default.
- W2376472016 hasConcept C2776530707 @default.
- W2376472016 hasConcept C2777397205 @default.
- W2376472016 hasConcept C2779134260 @default.
- W2376472016 hasConcept C2779383735 @default.
- W2376472016 hasConcept C2780479503 @default.
- W2376472016 hasConcept C3019114686 @default.
- W2376472016 hasConcept C71924100 @default.
- W2376472016 hasConcept C90924648 @default.
- W2376472016 hasConceptScore W2376472016C126322002 @default.
- W2376472016 hasConceptScore W2376472016C185592680 @default.
- W2376472016 hasConceptScore W2376472016C204232928 @default.
- W2376472016 hasConceptScore W2376472016C2775862500 @default.
- W2376472016 hasConceptScore W2376472016C2776530707 @default.
- W2376472016 hasConceptScore W2376472016C2777397205 @default.
- W2376472016 hasConceptScore W2376472016C2779134260 @default.
- W2376472016 hasConceptScore W2376472016C2779383735 @default.
- W2376472016 hasConceptScore W2376472016C2780479503 @default.
- W2376472016 hasConceptScore W2376472016C3019114686 @default.
- W2376472016 hasConceptScore W2376472016C71924100 @default.
- W2376472016 hasConceptScore W2376472016C90924648 @default.
- W2376472016 hasLocation W23764720161 @default.
- W2376472016 hasOpenAccess W2376472016 @default.
- W2376472016 hasPrimaryLocation W23764720161 @default.
- W2376472016 hasRelatedWork W2187038757 @default.
- W2376472016 hasRelatedWork W2350918383 @default.
- W2376472016 hasRelatedWork W2355221895 @default.
- W2376472016 hasRelatedWork W2358965343 @default.
- W2376472016 hasRelatedWork W2368150003 @default.
- W2376472016 hasRelatedWork W2369572764 @default.
- W2376472016 hasRelatedWork W2369794931 @default.
- W2376472016 hasRelatedWork W2377963978 @default.
- W2376472016 hasRelatedWork W2378804714 @default.
- W2376472016 hasRelatedWork W2382216357 @default.
- W2376472016 hasRelatedWork W2382554853 @default.
- W2376472016 hasRelatedWork W2383681249 @default.
- W2376472016 hasRelatedWork W2384031914 @default.
- W2376472016 hasRelatedWork W2386377897 @default.
- W2376472016 hasRelatedWork W2387473007 @default.
- W2376472016 hasRelatedWork W2388714429 @default.
- W2376472016 hasRelatedWork W2389839796 @default.
- W2376472016 hasRelatedWork W2391116340 @default.
- W2376472016 hasRelatedWork W2391473935 @default.
- W2376472016 hasRelatedWork W2393923197 @default.
- W2376472016 isParatext "false" @default.
- W2376472016 isRetracted "false" @default.
- W2376472016 magId "2376472016" @default.
- W2376472016 workType "article" @default.