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- W2376475132 abstract "Objective To observe the influence of propofol against the analgesic and hypnotic effects of isoflurane. Methods One hundred and twenty mice were randomly divided into 3 groups as hot-plate method(n=40,female),tail flick method(n=40,female and male) and hypnosis method(n=40,female and male).Each group was randomly divided into NS group(sodium chloride),Pp group(propofol),Iso group(isoflurane) and Pp+Iso group(propofol+isoflurane).Pain threshold in hot-plate test(HPPT) and tail flick latent period(TFL) were evaluated as analgesic effect.Sleeping latent period,sleeping time and falling asleep rate were evaluated as hypnotic effect.Results Compared with NS group,Pp group and Iso group,HPPT at 5,10 and 15 min and TFL at 5,10,15,20,25 and 30 min in Pp+Iso group extended(P0.01 or P0.05),as well as sleeping latent period shortened obviously(P0.01),sleeping time prolonged(P0.01) distinctly and falling asleep rate increased(P0.01) significantly.Conclusion Propofol can enhance the analgesic and hypnotic effects of isoflurane." @default.
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- W2376475132 date "2011-01-01" @default.
- W2376475132 modified "2023-09-25" @default.
- W2376475132 title "Influence of propofol against the analgesic and hypnotic effects of isoflurane" @default.
- W2376475132 hasPublicationYear "2011" @default.
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