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- W2376476880 abstract "OBJECTIVE:To develop a RP-HPLC method for the determination of salicylic acid in serum and to apply this method to the pharmacokinetic and bioavailability study of salycylic acid in compound aspirin preparations.METHODS:Waters2690HPLC instrument was used with Diamonsil C 18 column(5μm,250mm×4.6mm)as stationary phase and methanol-aceˉtonitrile-0.2%phosphoric acid(18∶32∶50)as mobile phase at a flow rate of1.0ml/min,and the detective wavelength was237nm.RESULTS:Calibration curve of salicylic acid was linear in the range of0.40～101.00μg/ml(r=0.9999).CONCLUS_ ION:The method is simple,sensitive,rapid and suitable for pharmacokinetic and bioavailability study of salicylic acid." @default.
- W2376476880 created "2016-06-24" @default.
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- W2376476880 date "2003-01-01" @default.
- W2376476880 modified "2023-09-25" @default.
- W2376476880 title "Determination of the Concentrations of Salicylic Acid in Serum With RP-HPLC and Its Application" @default.
- W2376476880 hasPublicationYear "2003" @default.
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