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- W2376532128 abstract "Objective:To compare the dissolution of satraplatin capsules with different particle sizes in water. Methods:The dissolution study of satraplatin was analyzed by ZRS-8G dissolution analyzer and Angilent 1100 high performance liquid phase chromatograph,following the standard ChP procedure.Results:Capsule satraplatin Ⅰ,with smaller particles(mean volume particle diameter d_v=2.04μm,half particle diameter d_(50)=1.04μm, 90% particle diameter d_(90)=4.89μm),dissolved much faster than capsule satraplatin Ⅱ,with larger particles (d_v=27.87μm,d_(50)=16.45μm,d_(90)=53.25μm).The dissolution at 30 min is 42% or 18%,at 60min 83% or 53% and the half time of dissolution 35.82min or 42.79min for capsule satraplatin Ⅰ or capsule satraplatin Ⅱ, respectively.Conclusion:Particle size had a dramatic effect on the drug dissolution in vitro.The smaller particles dissolved more rapidly and more efficiently than the larger ones." @default.
- W2376532128 created "2016-06-24" @default.
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- W2376532128 date "2006-01-01" @default.
- W2376532128 modified "2023-09-23" @default.
- W2376532128 title "The dissolution of satraplatin capsules in different particle sizes" @default.
- W2376532128 hasPublicationYear "2006" @default.
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