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- W2376539600 abstract "AIM:To evaluate the cytotoxicity of etoposide(VP16)on the U2-OS tumor cells and its mechanism.METHODS:The activity of VP16 with different grades of concentrations to U2-OS cells after 24h, 48 h,72 h and 96 h culture was detected by colorimetric MTF test.U2-OS cells apoptosis caused by reaction with VP16 was observed by flow cytometry(FCM).Transmission electron microscopy was applied to observe the morphologic changes of the bone sarcoma cells after treatment.RESULTS:VP16 inhibited the growth of os- teosarcomatous cells effectively in a time-dependent manner and dose-dependent manner with obvious increase of cell apoptosis,probably due to inducement.Transmission electron microscopy showed disappearance of nucleol and condensation of chromatin under the nucleonic membrane,and the typical morphologic apoptotic changes were not found in the control group.CONCLUSION:Etoposide can induce apoptosis of the U2-OS tumor cells with relation to the cytotoxicity and damage on osteosarcomateous cells." @default.
- W2376539600 created "2016-06-24" @default.
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- W2376539600 date "2006-01-01" @default.
- W2376539600 modified "2023-09-25" @default.
- W2376539600 title "Experimental study on apoptotic effect of etoposide on osteosarcoma cells" @default.
- W2376539600 hasPublicationYear "2006" @default.
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