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- W2376542012 abstract "Objective To investigate the plastic changes of neurons,astrocytes and microglials in rat midbrain and pons after a single intraperineal(IP)injection of lipopolysaccharide(LPS). Methods Anti-Fos,anti-GFAP,anti-OX42 single-labeling and Fos/GFAP double-labeling immunohistochemical ABC methods were used in this study. Results Fos(+)neurons were distributed in the superior colliculus,periaqueductal gray,parabrachial nuclei,locus ceruleus.The Fos(+) neurons appeared at 30min,and peaked at 1-3h after injection.The number of GFAP(+)astrocytes increased at 30 min,peaked at 1h,decreased at 3 h.Their bodies hypertrophied and processes thicken.OX42(+)microglials appeared firstly in periventricular gray at 30min after injection,peaked 6h.It became bigger and ramified.The distribution of Fos(+)neurons,GFAP(+)astrocytes and OX42(+)microglials were the same.Conclusion The neurons,astrocytes and microglials in superior colliculus,parabrachial nuclei and locus ceruleus might be involved in the neuroimmunomodulation of central nervous system to peripheral-immunity stimulate.The parabrachial nuclei may be a relay station of neuroimmunomodulation route." @default.
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- W2376542012 date "2005-01-01" @default.
- W2376542012 modified "2023-09-28" @default.
- W2376542012 title "THE EFFECT OF LIPOPOLYSACCHARIDE ON THE EXPRESSION OF FOS,GFAP AND OX42 IN RAT MIDBRAIN AND PONS" @default.
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