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- W2376555763 abstract "Objective To investigate the relationship between gastric motility,vasculopathy,and smooth muscle contraction function in diabetic rats.Methods Intraperitoneal injection streptozotocin was adopted to establish the diabetic model.After modeling 4 weeks and 24 weeks,the gastric emptying(GET1/2)and gastric emptying rate were measured by single photon emission computed tomography(SPECT)to determine the contraction function of the isolated gastric smooth muscle and the changes in gastric vascular using immunohistochemical methods.Results The gastric smooth muscle contraction frequency and amplitude of twenty-fourth week DM group is descend significantly,and the fourth week DM group is descend mildly. Observed on light microscope,the fourth week DM group,number of microvascular in gastric mucosa is increased,vascular endothelial cell is damaged slightly,submucosal and muscular vessels is fibrosised lightly;The twenty-fourth week DM group, vascular endothelial cell of submucous was shed significantly,vascular endothelial cell is damaged gravely,submucosal and muscular vessels is fibrosised seriously;blood vessel diameter ratio is reduced.Conclusion The changes in the contractile function of the gastric smooth muscle and vascular lesions might have caused diabetic gastric motility disorders." @default.
- W2376555763 created "2016-06-24" @default.
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- W2376555763 date "2013-01-01" @default.
- W2376555763 modified "2023-09-26" @default.
- W2376555763 title "Relationship between gastric motility,vasculopathy,and smooth muscle contractile in diabetic rats" @default.
- W2376555763 hasPublicationYear "2013" @default.
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