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- W2376582502 abstract "Objective:To study the effect of methylprednisolone(MP) on the proliferation of Schwann cell cultured in vitro.Method:Schwann cells were harvested and purified from sciatic nerve of adult SD rats.After culturing for 2 weeks,they were divided into 5 groups:the methylprednisolone groups(3 groups according to different concentration of methylprednisolone),NGF group and control group.The cell proliferation was observed through the phase contrast microscope.After culturing for 9 days,MTT assay was employed to observe the growth of Schwann cells.The samples were measured at wave length 570nm to compare the A values.Result:When methylprednisolone was 2 μg/ml,no obvious proliferation of Schwann cell was found.The A value of 0.2μg/ml methylprednisolone group was 0.376±0.079,20μg/ml methylprednisolone group was 0.280±0.086(P0.05) and control group was 0.252±0.115(P0.05).Which had significant differences.Conclusion:Methylprednisolone can accelerate Schwann cell proliferation in vitro.While overdose can reverse this process." @default.
- W2376582502 created "2016-06-24" @default.
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- W2376582502 date "2006-01-01" @default.
- W2376582502 modified "2023-09-23" @default.
- W2376582502 title "In vitro effect of methylprednisolone on the proliferation of Schwann cells" @default.
- W2376582502 hasPublicationYear "2006" @default.
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