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- W2376601668 abstract "Objective To explore the effect of raloxifene on bone density, sera E2 and IL-6, uterus endometrium in ovariectomized rats. Methods Forty-eight female Sprague-Dawley rats, aged 3 months were evenly divided into 4 groups randomly: sham group underwent sham ovariectomy, OVX group underwent bilateral ovariectomies, OVX+E2 group underwent bilateral ovariectomies followed by estrogens treatment, OVX+R group underwent ovariectomies followed by raloxifene treatment. These rats were killed after 3 months. The sera E2 and IL-6 were measured by radioimmunoassay. The endometrium was observed under microscope after HE staining. The bone density was tested by radioimn counter. Results The serum IL-6 in OVX+R Group was significantly higher than OVX group (P0.05), but serum E2 endometrium remained no different. Conclusion Raloxifene may play role in treatment of osteoporosis via decrease serum IL-6, but unrelated to E2 and not resulting in proliferation of uterus endometrium." @default.
- W2376601668 created "2016-06-24" @default.
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- W2376601668 date "2007-01-01" @default.
- W2376601668 modified "2023-09-27" @default.
- W2376601668 title "Effect of raloxifene on the bone density and sera estradiol and interleukin-6 in ovariectomized rats" @default.
- W2376601668 hasPublicationYear "2007" @default.
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