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- W2376619840 abstract "AIM: To assess the effects of taurine on regional cerebral blood flow (rCBF) and cerebral infarct volume in rats model of focal cerebral ischemia and reperfusion. METHODS: A focal cerebral ischemia and reperfusion model of rats was established with right cerebral middle artery occlusion (MCAO) method, and treated with taurine injection 10, 40, and 80 mg·kg -1, ip. Cortical rCBF was monitored before operation, at cerebral ischemia 1 h and reperfusion 30 min to each rat model. The neural function and infarct volume of each rat were determined after reperfusion 24 h. RESULTS: rCBF of all rats significantly decreased after MCAO, but CBF of taurine groups was obviously higher than that of model group both at ischemia and reperfusion stages .Infarction volume in model group was about (33±s 9)%, and that in taurine groups was (17±5) %, (12±5)%, and (11±3)%, respectively. It was significantly smaller than that of model group. Neurologic deficit score in taurine groups was smaller than that in model group, too. CONCLUSION: Taurine can increase rCBF and decrease cerebral infarct volume in rats model of focal ischemia. Taurine has a neuroprotective effect on cerebral ischemia." @default.
- W2376619840 created "2016-06-24" @default.
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- W2376619840 date "2004-01-01" @default.
- W2376619840 modified "2023-09-25" @default.
- W2376619840 title "Effects of taurine on cerebral blood flow and infarct volume in rat model of acute focal cerebral ischemia" @default.
- W2376619840 hasPublicationYear "2004" @default.
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