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- W2376621491 abstract "Objective To investigate the expression change of miRNA-92a in kidney ischemia/reperfusion(I/R) injury in mice.Methods Mice were subjected to a standard renal I/R to induce acute kidney injury(AKI) after 45 min of bilateral renal artery clamping.miRNA-92a expression changes used quantitative RT-PCR analysis at 4h and 24h.Results(1)Blood samples were obtained at 24 h and at the time of animal death to evaluate the degree of AKI according to serum creatinine(SCr) and urea nitrogen(UN)(P0.05),and the renal tissues were obtained to evaluate histological changes after I/R at 24h.(2) Quantitative RT-PCR analysis showed that ischemic kidney injury significantly increased miRNA-92a expression compared to the sham controls,with prominent changes at 4h and 24h after reperfusion(n=3each,P0.05).Conclusions Renal I/R to induce AKI significantly increased miRNA-92a expression compared to the sham-operated controls,with prominent changes at 4h and 24h after reperfusion.These results provided evidence that miRNA-92a may be involve the mechanisms of ischemic injury disease and controlled angiogenesis." @default.
- W2376621491 created "2016-06-24" @default.
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- W2376621491 date "2010-01-01" @default.
- W2376621491 modified "2023-09-27" @default.
- W2376621491 title "Expression of miRNA-92a affected by renal ischemia/reperfusion injury in mice" @default.
- W2376621491 hasPublicationYear "2010" @default.
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