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- W2376630709 abstract "Objective:To observe the alteration of CXCL16 in different patients,and explore its relation with coronary heart disease(CHD) and clinical significance.Method:Patients(n=88) received coronary angiography were selected,and divided into three groups: acute coronary syndrome group(ACS,n=32),stable angina pectoris group(SAP,n=31),normal control group(n=25).The baseline of CXCL16,hsCRP and IL-18 were detected,the major adverse cardiac event(MACE) were followed up in the first,third and sixth month.Result:Serum levels of CXCL16,hsCRP and IL-18 were significantly higher in ACS patients than in SAP patients and control group(P0.01),there was also significant difference between SAP group and control group in serum levels of CXCL16 and IL-18(P0.05).The level of serum CXCL16 was positively correlated with serum hsCRP(r=0.437,P0.01),IL-18(r=0.552,P0.01) and HDL(r=-0.321,P0.01) levels,no correlation was found amomg other indexes according to the correlation analysis.All the patients were divided into two groups on the basis of the mean level of CXCL16: CXCL162 246.97 ng/L,CXCL16≤2 246.97 ng/L,there were no significant difference in histories of smoking,family history,hypertension and diabetes mellitus between the two groups(P0.05).Multiple logistic regression analysis revealed that CXCL16 and hsCRP were the important risk factors of ACS.The incidence of cardiac events of ACS group was higher than SAP group,but there was no significant difference between them.Only hsCRP entered the model of logistic regression analysis(in the third and sixth month),it may be a predictor of MACE in patients with CHD except CXCL16.Conclusion:CXCL16 is an independent risk factor of CHD besides traditional ones,it may be more beneficial to predicting acute cardiovascular event by combination detection of serum levels of CXCL16 and hsCRP." @default.
- W2376630709 created "2016-06-24" @default.
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- W2376630709 date "2009-01-01" @default.
- W2376630709 modified "2023-09-28" @default.
- W2376630709 title "Alteration and clinical significance of CXCL16 in patients with coronary heart disease" @default.
- W2376630709 hasPublicationYear "2009" @default.
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