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- W2376650002 abstract "Objective To investigate whether or not pre treatment with pergolide, could protect rat against 6 hydroxydopamine(6 OHDA) induced injury to dopaminergic(DA) neuron in the substantia nigra.Methods Unilateral PD rat models were made by injecting stereotaxically 6 OHDA.The effects of pre treatment with pergolide on the apomorphine(APO) induced rotational behavior and the pathological changes of substantia nigra on the lesion side were observed.Results Pre treatment with pergolide for 7 days significantly decreased the rotational behavior and the redamage of the DA neurons on the lesion side in PD rat models. Pretreatment with sulpiride,a DA D 2 antagonist,abolished the neuroprotection of pergolide.Conclusion Pergolide could provide neuroprotection to DA neuron, and its mechanism was possibly associated with stimulation of the DA D 2 receptor." @default.
- W2376650002 created "2016-06-24" @default.
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- W2376650002 date "2003-01-01" @default.
- W2376650002 modified "2023-09-23" @default.
- W2376650002 title "Primary investigation of protective effect of pergolide on parkinsonian rat" @default.
- W2376650002 hasPublicationYear "2003" @default.
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