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- W2376650702 abstract "sFlt-1 and Flt-1 belong to the vascular endothelial growth factor receptor(VEGFR),sFlt-1 competition binding with VEGF,completely abolished the biological activity of VEGF,inhabited angiogenesis and affected the vascular wall barrier integrity and permeability.Placental growth factor(PLGF) is a member of the VEGF family,PLGF binds with Flt-1 receptor,and promotes angiogenesis and trophoblast proliferation.These biological functions can be blocked by sFlt-1 receptor,sFlt-1 plays an important role in regulate PLGF.sFlt-1 concentrations are higher in preeclampsia serum and prior to the onset of the disease.Levels of PLGF are lower in preeclampsia serum compare to normal.sFlt-1 plays a major role in the pathogenesis of preeclampsia,it is unclear how hypoxia regulates placental sFlt-1 expression,maybe the PI3K-Akt pathway plays an important role in regulating the expression of sFlt-1.sFlt-1 and PLGF might be used as markers for predicting preeclampisa." @default.
- W2376650702 created "2016-06-24" @default.
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- W2376650702 date "2012-01-01" @default.
- W2376650702 modified "2023-09-27" @default.
- W2376650702 title "sFlt-1,PLGF and Their Role in Pathogensis and Prediction of Preeclampsia" @default.
- W2376650702 hasPublicationYear "2012" @default.
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