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- W2376673089 abstract "To elucidate the effect of the combination of cytokines on ex vivo expansion and self-renewal potential of human umbilical cord blood hematopoietic stem/progenitor cells.CD34+ cells from cord blood were expanded for 14 days in the culture containing FL + Tpo + SCF + IL-6 + IL-3 + G-CSF and the expanded cells were transplanted into sublethally irradiated SCID mice.The expanded cells were engrafted smoothly in the SCID recipients and reconstituted their hematopoiesis. Furthermore, human hematopoietic cells could be detected in the marrow of the recipients 6 weeks after transplantation.It is possible to expand hematopoietic cells ex vivo efficiently and maintain concomitantly their self-renewal and hematopoietic reconstitution capacities by the combination of FL + Tpo + SCF + IL-6 + IL-3 + G-CSF." @default.
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- W2376673089 date "1999-12-01" @default.
- W2376673089 modified "2023-09-25" @default.
- W2376673089 title "[Studies on hematopoietic reconstitution by ex vivo expanded human cord blood hematopoietic stem/progenitor cells in SCID mice]." @default.
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