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- W2376673149 abstract "Objective To investigate the mechanism underlying up-regulation of ICAM-1 and VCAM-1expression induced by high glucose in endothelial cells. Methods Cultured human umbilical vein endothelial cells (HUVECs) were treated with 20 mmol/L glucose, and cellular reactive oxygen species (ROS) level was detected by flow cytometry. Western blot was applied to analyse expression and phosphorylation of IκB and NF-κB. The activation of NF-κB was measured by immunofluorescence. Results Treatment of HUVECs with 20 mmoL/L glucose decreased IKB level and stimulated the phosphorylation of IκB and NF-κB, and accompanied by increased ROS level. NF-κB was translocated into nucleus where NF-κB up-regulated the expressions of inflammatory factors such as ICAM-1 and VCAM-1. Conclusions High glucose upregulates the expressions of ICAM-1 and VCAM-1 via the stimulation of ROS generation and the activation of NF-κB pathway." @default.
- W2376673149 created "2016-06-24" @default.
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- W2376673149 date "2010-01-01" @default.
- W2376673149 modified "2023-09-25" @default.
- W2376673149 title "Mechanism underlying up-regulation of ICAM-1 and VCAM-1expressions induced by high glucose in endothelial cells" @default.
- W2376673149 hasPublicationYear "2010" @default.
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