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- W2376683399 abstract "OBJECTIVE:To study the killing effect of double suicide genes system on K562 cells in vivo and in vitro.METHODS: CDglyTK gene was transfected into K562 cells by using lipofectamine.K562 cells were infected with viral supernant.K562/CDgly TK cells were treated with 5-FC and/or GCV.The mice were divided into three groups randomly: tumor formation group,tumor inhibition group and tumor therapy group.Each mouse was implanted with(K562/CDgly) TK cells or K562 cells.RESULTS: The killing effect of 5-FC and GCV in combination on K562/CDglyTK was more effective than that of using 5-FC or GCV alone.In vivo study,the rate of tumor formation was 100%.Double suicide genes could suppress tumor formation of K562/CDglyTK cells.After the mice were treated with double suicide genes,the median tumor volume of mice implanted with K562/CDglyTK cells decreased obviously compared with the control group.Their median survival was significantly prolonged.CONCLUSIONS: Double suicide genes are more effective for killing effect on K562 cells in vivo and in vitro.It may be applicable for clinical gene therapy." @default.
- W2376683399 created "2016-06-24" @default.
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- W2376683399 date "2006-01-01" @default.
- W2376683399 modified "2023-09-25" @default.
- W2376683399 title "Killing effect of double suicide genes mediated by lentivirus on K562 cells" @default.
- W2376683399 hasPublicationYear "2006" @default.
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