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- W2376688863 abstract "Objective To assess the therapeutic effects of three kinds of sequential therapy regimens according to the cell cycle on adriamycin-induced nephropathy(AIN)rats. Methods Rat AIN model was established.SD rats were randomly divided into 6 groups:normal control group(n=6),AIN model group(n=8),Mp+Cs+CTX group(n=8),Mp+Rap+CTX group(n=8),and Mp+LEF+CTX group(n=8).The rats in treatment groups were treated for 4 weeks.The level of 24 h urinary protein,serum total protein(TP),albumin(ALB),alanine aminotransferase(ALT),aspartate aminotransferase(AST)were measured. Results The level of 24 h urinary protein in AIN model group was significantly higher than in the other four groups.The level of TP in AIN model group was significantly lower than in normal control group,Mp+Cs+CTX group and Mp+Rap+CTX group.The level of ALB was significantly lower in AIN model group than in the other four groups.The level of 24 h urinary protein,TP and ALB in Mp+Cs+CTX group had more obvious changes than in Mp+Rap+CTX group and Mp+LEF+CTX group. Conclusion According to the theory of cell cycle,three kinds of sequential combined regimens could decrease the excretion of urinary protein and increase the level of serum protein in adriamycin-induced nephropathy rats.The Mp+Cs+CTX has the better therapeutic effects." @default.
- W2376688863 created "2016-06-24" @default.
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- W2376688863 date "2010-01-01" @default.
- W2376688863 modified "2023-09-23" @default.
- W2376688863 title "Efficacy of sequential therapy according to the cell cycle for the adriamycin-induced nephropathy rats" @default.
- W2376688863 hasPublicationYear "2010" @default.
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