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- W2376691421 abstract "Objective To assess the efficacy and safety of topiramate monotherapy in the treatment of alcohol dependence.Methods The Cochrane library, Pun Med, EMBase, CNKI, VIP and CBM database were searched to collect the randomized contolled trials(RCTs) of topiramate monotherapy to compare with placebo or positive control drug in alcohol dependence. Data were extracted from the included literatures after the literatures' qualities were assessed. The meta-analyses were conducted with Rev Man 5.2 software.Results Thirteen trials were included. Compared with placebo, topiramate reduced score of obsessive compulsive drinking scale(MD=-5.90,95%CI:-10.99~-0.82,P=0.02), decreased drinks per drinking day(MD=-6.94,95%CI:-12.20~-1.68,P=0.01), and increased percentage of days abstinent(MD=15.36,95%CI:4.15~6.56,P0.01). The incidence of paraesthesia, taste perversion, weight loss, memory or concentration impairment, dizziness, psychomotor retardation in topiramate group was higher. But the incidence of other adverse events was similar between groups. Compared with naltrexone, topiramate significantly postponed the days to first relapse(MD=2.10,95%CI:0.23~3.97,P=0.03). The adverse events were similar between groups.Conclusion sTopiramate in treatment of alcohol dependence is effective and safety." @default.
- W2376691421 created "2016-06-24" @default.
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- W2376691421 date "2015-01-01" @default.
- W2376691421 modified "2023-09-24" @default.
- W2376691421 title "Topiramate monotherapy for alcohol dependence:a meta-analysis" @default.
- W2376691421 hasPublicationYear "2015" @default.
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