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- W2376702901 abstract "Objective: To set up animal model of pterygium in rabbit eye. Methods: Removal of corneal limbal stem cells of superior temporal quadrant and stimulating of 1.25 percent diluted hydrochloric acid to establish pterygium model in rabbit eyes. The condition of corneal epithelial defect、conjunctival congestion and new organizations was observed every weekend. Rabbits were executed by end of the fourteenth week, and samples of corneal marginal were took respectively (four experimental group and four control group) for hematoxylin and eosin staining. Results: We didn’t build a successful pterygium model in rabbit eyes. There was no new limbal organization and only slightness proliferation of fornix conjunctive in two eyes within fourteen weeks. The result of HE staining showed a large number of hyperplasia of limbal epithelial cells, and the tissue of basal layer was loose and had inflammatory cells in the experimental group, while the structure of corneal limbus was almost integrity in the control group. Conclusion: There may be two possible explanations for the failure of its model: firstly: The pathogenesis of pterygium might be so complex that only by removal of corneal limbal stem cells and stimulation of hydrochloric acid can not lead to the occurrence of pterygium; secondly, pterygium may be leaded by removal of corneal limbal stem cells and stimulation of hydrochloric acid, and the result of our experiment are false-negative. The animal model of pterygium is not yet mature so far and need further study." @default.
- W2376702901 created "2016-06-24" @default.
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- W2376702901 date "2013-01-01" @default.
- W2376702901 modified "2023-09-27" @default.
- W2376702901 title "Experiment of pterygium model in rabbit eye" @default.
- W2376702901 hasPublicationYear "2013" @default.
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