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- W2376716847 abstract "Objective To study the serum levels of tumor necrosis factor (TNF-α), interleukin 6 (IL-6), serum calcium and the expression of parathyroid hormone receptor (PTHR) in rats with severe acute pancreatitis (SAP), and to investigate the changes after methylprednisolone intervention. Methods Thirty-six male SD rats were divided randomly into three groups :sham operation group (SO), SAP group and SAP methylprednisolone treatment group (SAP+ MP), 12 rats in each group. SAP model was made by injecting 5% sodium deoxycholate into biliary-pancreatic duct. Serum calcium, amylase, TNF-α, IL-6, volume of ascites and histological change of pancreas were determined. The expression of PTHR mRNA in the rat kidney and bone was detected by RT-PCR. Results The serum TNF-α and IL-6 levels in SAP group were significantly increased after SAP onset. Meanwhile, the expression of PTHR mRNA in the rat kidney and bone was decreased (P0. 01), and the concentration of serum calcium remarkably reduced, especially 12 h after SAP onset. The levels of serum TNF-α and IL-6 had a negative correlation to the concentration of serum calcium and the expression of PTHR mRNA. As compared with SAP group, the levels of serum TNF-α and IL-6 were significantly decreased and the expression of PTHR mRNA elevated (P0.01) in SAP+ MP group. The hypocalcemia was significantly alleviated, the pancreatic pathological changes attenuated, and the survival rate increased. Conclusion The decreased expression of PTHR mRNA in kidney and bone is one of the vital causes of hypocalcemia in SAP, probably through the excessive release of inflammtory cytokines. Methylprednisolone can inhibit the release of inflammatory cy-tokines, increase the expression of PTHR mRNA and improve hypocalcemia." @default.
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- W2376716847 date "2006-01-01" @default.
- W2376716847 modified "2023-09-26" @default.
- W2376716847 title "Influence of methylprednisolone on hypocalcemia and the expression of parathyroid hormone receptor in severe acute pacreatitis rats" @default.
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