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- W2376719580 abstract "OBJECTIVE: To study the effect and mechanism of apoptosis of HL-60 cells induced by polysaccharide PSM from Polyporus sp.M05.METHODS: The proliferation and inhibition were studied by the method of leukocyte counting.The cell morphology was detected through a inverted microscope.The cell cycle and apoptosis were analyzed by flow cytometry with propidium iodide staining.Semi-quantitative RT-PCR was used to detect the mRNA expression of the apoptosis gene.RESULTS: PSM significantly inhibited the proliferation of HL-60 cells.The apoptosis bodies were obviously detected through the inverted microscope.After being induced by PSM,the cell cycle was significantly arrested at the G0/G1 phase.The apoptosis ratio was increased significantly in a time and dose manner.After being induced by PSM,mRNA of Bcl-2 was down regulated and mRNA(s) of Bax,Fas,Caspase were up regulated.CONCLUSIONS: The mechanism of HL-60 cell apoptosis induced by PSM is related to the up-regulation of Bax,Fas,Caspase and down-regulation of Bcl-2,and involved in the death receptor pathway and mitochondia pathway." @default.
- W2376719580 created "2016-06-24" @default.
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- W2376719580 date "2010-01-01" @default.
- W2376719580 modified "2023-09-26" @default.
- W2376719580 title "Effect and mechanism of apoptosis HL-60 cells induced by a fungus polysaccharide" @default.
- W2376719580 hasPublicationYear "2010" @default.
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