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- W2376728662 abstract "Objective To explore the mechanism of action for oxidative damnification of alveolar tissues induced by BaP and investigate whether astragalus membranaceus plays a protective role or not. Methods Viripotent 100 male SD rats were randomly divided into group A,B,C,D and E( n = 20). The rats were lavaged with 1 mg /( kg·d) BaP in group A,B,C and D, while the rats in group A,B and C were given additional astragalus injection with a dose of 10,20 and 40 g /( kg·d) respectively, and group E was lavaged with olive oil and injected with 0. 9% sodium chloride injection. The oxydic and antioxidative indexes were detected after continuous intravenous injection for 15 d. Results The activities of glutathione peroxidase( GSH-PX) and superoxide dismutase( SOD) in alveolar tissues in group B,C and D were significantly superior than those in group A,but were significantly lower than those in group E( P 0. 05); the activities of reactive oxygen species( ROS) and the concentration of malondialdehyde( MDA) in alveolar tissues in group B,C and D were significantly inferior to those in group A,but were significantly superior to those in group E( P 0. 05). Conclusion Astragalus membranaceus can inhibit the depressed activity of GSH-PX and SOD induced by BaP,and can inhibit the raised activity of ROS and concentration of MDA induced by BaP in alveolar tissues." @default.
- W2376728662 created "2016-06-24" @default.
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- W2376728662 date "2013-01-01" @default.
- W2376728662 modified "2023-09-24" @default.
- W2376728662 title "Effect of Astragalus Membranaceus on Oxidation of Relevant Materials of Alveolar Tissues induced by BaP" @default.
- W2376728662 hasPublicationYear "2013" @default.
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