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- W2376734846 abstract "Objective:To explore the circadian rhythm of immune system in liver cancer rats. Methods: The Wistar rats which were adapted to synchronized with an alternation of 12 h of light(L) and 12 h of darkness(D)(LD12:12) were planted cancer piece into liver. After 4 weeks, the blood samples as well as the normal were collected 6 times a day(8:00,12:00,16:00、20:00、24:00、4:00 ). The number of WBC, percentage of neutrophil and lymphocyte were detected by cell-counter. Level of interleukin 2(IL-2) and interleukin 6(IL-6) were measured by using ELISA technique. Results: The immune system of liver cancer rats demonstrated difference from the normal group. The number of WBC in circulation exposed similar rhythm with the normal and that got to its peak value at the hour of 12:00～16:00 and followed by a trough at 8:00. The whole rhythm showed as ladle-like, but the phase weakened. The acrophase in percentage of neutrophil and lymphocyte showed the reverse type and single peak. The acrophase of the level of IL-2 had a tendency to go forward than the normal group and that got to peak value at 12:00 hour but lowered at 8:00. No diurnal rhythm of IL-6 was observed. While rhythm of IL-6 showed a variation like “W”, the peak value was seen at the hour of 4:00 and 16:00 and then followed by a lowest point at 12:00 hour in normal group. Conclusion: This finding suggests that immune system in normal rats exists circadian rhythm and alteration in rats with liver cancer. The development of liver cancer may correlate with the rhythm of immune system, which will provide a theoretical source for researching chrono-pharmacology ,chrono-immunology and chrono-therapy." @default.
- W2376734846 created "2016-06-24" @default.
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- W2376734846 date "2006-01-01" @default.
- W2376734846 modified "2023-09-24" @default.
- W2376734846 title "Experimental study on circadian rhythm of immune system in rats with liver cancer" @default.
- W2376734846 hasPublicationYear "2006" @default.
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