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- W2376736227 abstract "Objective IGF-1 is one of the most abundant growth factors in bone marrow stromal cells,which,as well as VEGF,plays an important role in promoting new bone formation or bone healing process.To investigate how to induce VEGF,exogenous IGF-1was added to bone marrow stromal cells in vitro,then some signaling protein Inhibitors was used to determine the role of signaling proteins related.Methods By western blot,the expression of VEGF and signaling proteins-HIF-1α,p-MEK,p-ERK,p-MNK and p-eIF-4E was detected.The experiment was divided into four groups:(1)control group,(2)50ng/ml IGF-1,(3)CGP 57380-MNK inhabitor,and(4)50ng/ml IGF-1 and 5ng/ml HIF-1αinhabitor YC-1.Results Expression of these sinaling proteins and VEGF were upgraded after exogenous IGF-1,while increasing expression of VEGF is blocked by MNK inhabitor or HIF-1 αinhabitor.Conclusion IGF-1regulated the expression of VEGF through ERK-MNK signal transduction." @default.
- W2376736227 created "2016-06-24" @default.
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- W2376736227 date "2013-01-01" @default.
- W2376736227 modified "2023-09-23" @default.
- W2376736227 title "Experiment study of IGF-1 induces VEGF expression by ERK-MNK signaling pathway in bone marrow mesenchymal stem cells" @default.
- W2376736227 hasPublicationYear "2013" @default.
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