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- W2376742410 abstract "Objective To observe the effect of Roux-en-Y gastric bypass(RYGB)treatment and hepatic branch of the vagus on hypoglycemic outcome and glucagon-like peptide-1(GLP-1)in rats with type 2 diabetes,and the interaction of between the two.Methods Totally 45 type 2 diabetic rats were divided into four groups:sham operation(S group,n=10),sham operation with hepatic branch of the vagus resected(SV group,n=11),RYGB group(n=12),and RYGB with hepatic branch of the vagus resected(RYGBV group,n=12).The body mass,fasting blood-glucose(FBG),fasting serum insulin(FINS)and concentrations of fasting serum GLP-1 were examined before and after surgery.Effects of RYGB and the hepatic branch of the vagus on GLP-1 levels were analyzed.Results Compared with S group and RYGBV group,RYGB group had significantly decreased body mass(P0.05)and significantly improved levels of serum GLP-1 and insulin(P0.05);FBG level in RYGB group was significantly lower than that in S group(P0.05)and similar to that in RYGBV group.The effect of RYGB on fasting serum GLP-1 was stronger than that of liver branch of the vagus nerve,and there was interaction between the two(P0.05).Conclusion RYGB treatment has satisfactory treatment effect for type 2diabetes,and care should be taken during RYGB surgery to preserve the hepatic branch of the vagus." @default.
- W2376742410 created "2016-06-24" @default.
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- W2376742410 date "2014-01-01" @default.
- W2376742410 modified "2023-09-23" @default.
- W2376742410 title "Impact of gastric bypass treatment and hepatic branch of the vagus on hypoglycemic outcome in rats with type 2 diabetes" @default.
- W2376742410 hasPublicationYear "2014" @default.
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