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- W2376758314 abstract "Objective To evaluate the protective effect of complement inhibition on acute lung injury(ALI)induced by lipopolysacharide(LPS).Methods Cobra venom factor(CVF)and LPS were used to deplete complement and injury lung,respectively.Forty male adult SD rats were randomly divided into five groups:LPS group,three CVF groups and normal saline control group.5 mg/kg of LPS were injected into rats via tail vein to form ALI model.In CVF groups,50U/kg of CVF was injected into rat tail vein prior to LPS administration 24hlater.Then samples of 0.5,2and 4h,respectively,were collected.PMN count,TNF-,IL-8and ICAM-1in broncho alveolar lavage fluid(BALF),serum complement activity,protein concentration,lung permeability,and wet-todry weight ratio were measured.The change of pathology in lung tissue was observed by pathological section.Results Lung injury in rats received complement inhibition was significantly attenuated compared with that in LPS group by histopathology check.In CVF groups,wet-to-dry weight ratio,PMN count,lung alveolar permeability index were significantly decreased compared with those in LPS group.No significant difference was shown between control and CVF groups in parameters mentioned above.Although the levels of TNF-α,IL-8and ICAM-1in BALF of CVF groups were lower than that of LPS group,no significant difference was shown between them.Conclusion Complement plays an important role in the early process of ALI induced by LPS.Complement inhibition can attenuate lung tissue damage and inhibit neutrophil migration to the lung and bronchoalveolar vascular leakage in the early period of ALI." @default.
- W2376758314 created "2016-06-24" @default.
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- W2376758314 date "2010-01-01" @default.
- W2376758314 modified "2023-09-23" @default.
- W2376758314 title "Protective effect of complement inhibition on acute lung injury in rats induced by lipopolysacharide" @default.
- W2376758314 hasPublicationYear "2010" @default.
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