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- W2376762090 abstract "AIM To investigate the relationship between plasmic diamine oxidase (DAO) and gut injury in acute necrotizing pancreatitis (ANP). METHODS ANP was induced by injection of sodium taurocholate with trypsin into the pancreatic duct in 8 dogs during abdominal operation. Serum levels of amylase was determined, DAO activities of plasma and ileal mucosa were measured dynamically. RESULTS In ANP group, the levels of plasmic DAO increased significantly in the first ( mol/s ,0 025±0 006 vs 0 011±0 002) and the second day ( mol/s ,0 019±0 005 vs 0 012±0 003), but after the fourth day ( mol/s ,0 006±0 001 vs 0 014±0 002) it decreased. The levels of DAO in ileum were also lowered. Serum levels of amylase was increased 3-10 times. ANP induced damage of epithlial villi of the mucosa and bacterial translocation was found in liver, pancreas, kidney, lung, spleen and mesenteric lymph nodes of all animals. CONCLUSION Plasma DAO level might reflect the damage of intestinal mucosa in ANP, and bacterial translocation is the result of the gut injury." @default.
- W2376762090 created "2016-06-24" @default.
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- W2376762090 date "1999-01-01" @default.
- W2376762090 modified "2023-09-28" @default.
- W2376762090 title "Effect of DAO on intestinal damage in acute necrotizing pancreatitis in dogs" @default.
- W2376762090 hasPublicationYear "1999" @default.
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