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- W2376778799 abstract "Objective:The protective effect of PTD-kallikrein on cerebral ischemia-reperfusion injury induced by MCA occlusion has been explored in rats.Methods:PTD-kallikrein was prepared by chemical synthesis.Cerebral ischemia-reperfusion model was generated by occluding the left middle cerebral artery(MCA)for 90 minutes through the intraluminal thread technique and followed by reperfusion in rats.The rats were then treated by normal saline,Kallikrein,PTD-kallikrein and PTD-kallikrein plus bradykinin B2 receptor antagonist individually.After the neurologic functions were appraised by NSS,the rats were decapitated.The infarct volume was determined by TTC stain and the concentrations of cell factors IL-1β,TNF-α,and PGE2 in ischemic tissues were measured by ELISA.Results:PTD-kallikrein was found to improve the disordered neurologic functions caused by cerebral ischemia,to decrease the infarct volume,and to inhibit the releases of IL-1β,TNF-α,and PGE2.However,Bradykinin B2 receptor antagonist was discovered to significantly block the effect of PTD-kallikrein.Conclusion:PTD-kallikrein has a neuroprotective action in the cerebral ischemia-reperfusion injury induced by MCA occlusion in rats to some degree,possibly through bradykinin B2 receptor system." @default.
- W2376778799 created "2016-06-24" @default.
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- W2376778799 date "2007-01-01" @default.
- W2376778799 modified "2023-09-25" @default.
- W2376778799 title "Protective Effect of PTD-kallikrein on Cerebral Ischemia-reperfusion Injury Induced by MCA Occlusion in Rats" @default.
- W2376778799 hasPublicationYear "2007" @default.
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