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- W2376802981 abstract "Objective:To explore the mechanism of breviscapine at molecular level by investigating the effect of breviscapine on calcium-activated potassium channels(K_(Ca)) in rat aortic smooth muscle.Method:Wistar rats were used,and the action of breviscapine on K_(Ca) was studied in rat aortic smooth muscle using the Patch-clamp technique. Result:In cell-attached patch,both the channel open probability(Po) and the channel conductance were enhanced by the application of breviscapine.When the concentration of breviscapine was 5×10~(-4),10~(-3),1.85×10~(-3)mol/L,the Po was increased from(0.012±0.047) to(0.427±0.364),P0.05,0.609±0.312(P0.05),0.839±0.192(P0.05) respectively,and the channel conductance was increased from(124±59) pS to(174±83)pS,(199±41)pS(P0.05),(269±85)pS(P0.01) respectively.Conclusion:Breviscapine may activate K_(Ca) and play a role in dilating vasculature." @default.
- W2376802981 created "2016-06-24" @default.
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- W2376802981 date "2006-01-01" @default.
- W2376802981 modified "2023-09-25" @default.
- W2376802981 title "Activation of breviscapine to calcium-activated potassium channels in rat aortic smooth muscle" @default.
- W2376802981 hasPublicationYear "2006" @default.
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