Matches in SemOpenAlex for { <https://semopenalex.org/work/W2376813553> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2376813553 abstract "Objective To investigate the effects of propofol on lung nitric oxide synthase (NOS) in rats and the mechanism of its pulmonary artery and bronchus dilating effects. Methods Forty SD rats weighing (210+40)g were randomly divided into two groups: propofol group received propofol 100mg-kg-1 ip and when its righting reflex was lost propofol was continuously infused at 10mg'kg-1 h-1 through the vein in the tail for 10min, then the animal was killed; control group received normal saline 10 ml'kg-1 ip and the animals were killed 20 min later. After sacrificing the animals the chest was opened and the lungs were removed. The NO level in the broncho-alveolar lavage fluid (BALF) was measured in 10 animals. NOS activity and NO content of the lung tissue homogenate were examined in 10 animals. Cellular distribution and expression of endothelial NOS (eNOS) and neural NOS (nNOS) in the lung were examined by immunohistochemistry in 5 animals. Results The NO level in BALF, NO content and NOS activity in the lung homogenate were significantly higher in propofol group than those in control group (P 0.01), Immunohistochemistry showed that the expressions of nNOS and eNOS were significantly more positively in propofol group than those in the control group. Conclusion Propofol can stimulate the NOS activity in the lung and raise the level of endogenous NO which plays an important role in dilating pulmonary artery and bronchus." @default.
- W2376813553 created "2016-06-24" @default.
- W2376813553 creator A5006294278 @default.
- W2376813553 creator A5061320362 @default.
- W2376813553 creator A5091772988 @default.
- W2376813553 date "1997-01-01" @default.
- W2376813553 modified "2023-09-23" @default.
- W2376813553 title "The effects of propofol on lung nitric oxide synthase activity in rats" @default.
- W2376813553 hasPublicationYear "1997" @default.
- W2376813553 type Work @default.
- W2376813553 sameAs 2376813553 @default.
- W2376813553 citedByCount "0" @default.
- W2376813553 crossrefType "journal-article" @default.
- W2376813553 hasAuthorship W2376813553A5006294278 @default.
- W2376813553 hasAuthorship W2376813553A5061320362 @default.
- W2376813553 hasAuthorship W2376813553A5091772988 @default.
- W2376813553 hasConcept C126322002 @default.
- W2376813553 hasConcept C131783052 @default.
- W2376813553 hasConcept C134018914 @default.
- W2376813553 hasConcept C142724271 @default.
- W2376813553 hasConcept C204232928 @default.
- W2376813553 hasConcept C2776178081 @default.
- W2376813553 hasConcept C2776277131 @default.
- W2376813553 hasConcept C2777397205 @default.
- W2376813553 hasConcept C2777622882 @default.
- W2376813553 hasConcept C2777714996 @default.
- W2376813553 hasConcept C2778326061 @default.
- W2376813553 hasConcept C2779698670 @default.
- W2376813553 hasConcept C2780314925 @default.
- W2376813553 hasConcept C2780940725 @default.
- W2376813553 hasConcept C42219234 @default.
- W2376813553 hasConcept C519581460 @default.
- W2376813553 hasConcept C71924100 @default.
- W2376813553 hasConcept C83974742 @default.
- W2376813553 hasConceptScore W2376813553C126322002 @default.
- W2376813553 hasConceptScore W2376813553C131783052 @default.
- W2376813553 hasConceptScore W2376813553C134018914 @default.
- W2376813553 hasConceptScore W2376813553C142724271 @default.
- W2376813553 hasConceptScore W2376813553C204232928 @default.
- W2376813553 hasConceptScore W2376813553C2776178081 @default.
- W2376813553 hasConceptScore W2376813553C2776277131 @default.
- W2376813553 hasConceptScore W2376813553C2777397205 @default.
- W2376813553 hasConceptScore W2376813553C2777622882 @default.
- W2376813553 hasConceptScore W2376813553C2777714996 @default.
- W2376813553 hasConceptScore W2376813553C2778326061 @default.
- W2376813553 hasConceptScore W2376813553C2779698670 @default.
- W2376813553 hasConceptScore W2376813553C2780314925 @default.
- W2376813553 hasConceptScore W2376813553C2780940725 @default.
- W2376813553 hasConceptScore W2376813553C42219234 @default.
- W2376813553 hasConceptScore W2376813553C519581460 @default.
- W2376813553 hasConceptScore W2376813553C71924100 @default.
- W2376813553 hasConceptScore W2376813553C83974742 @default.
- W2376813553 hasIssue "11" @default.
- W2376813553 hasLocation W23768135531 @default.
- W2376813553 hasOpenAccess W2376813553 @default.
- W2376813553 hasPrimaryLocation W23768135531 @default.
- W2376813553 hasRelatedWork W2005906172 @default.
- W2376813553 hasRelatedWork W2101448523 @default.
- W2376813553 hasRelatedWork W2298773681 @default.
- W2376813553 hasRelatedWork W2353085056 @default.
- W2376813553 hasRelatedWork W2354802328 @default.
- W2376813553 hasRelatedWork W2356327976 @default.
- W2376813553 hasRelatedWork W2361101255 @default.
- W2376813553 hasRelatedWork W2364423691 @default.
- W2376813553 hasRelatedWork W2365941616 @default.
- W2376813553 hasRelatedWork W2367081497 @default.
- W2376813553 hasRelatedWork W2368560431 @default.
- W2376813553 hasRelatedWork W2368700262 @default.
- W2376813553 hasRelatedWork W2369912292 @default.
- W2376813553 hasRelatedWork W2370661122 @default.
- W2376813553 hasRelatedWork W2371760792 @default.
- W2376813553 hasRelatedWork W2373892330 @default.
- W2376813553 hasRelatedWork W2375480490 @default.
- W2376813553 hasRelatedWork W2387395392 @default.
- W2376813553 hasRelatedWork W3147321088 @default.
- W2376813553 hasRelatedWork W3150454542 @default.
- W2376813553 isParatext "false" @default.
- W2376813553 isRetracted "false" @default.
- W2376813553 magId "2376813553" @default.
- W2376813553 workType "article" @default.