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- W2376849610 abstract "To approach the effect of low molecular weight heparin(LMWH) on rat renal ischemia reperfusion injury by observing the expression of intercellular adhesion molecular-1(ICAM-1) and NF-kappaB(NF-κB) in renal heterophil granulocytes.The model for rat renal ischemia reperfusion injury was established.80 healthy Wistar rats were equally randomized into following groups: the blank control group,sham-operated control group,IRI control group and LMWH treatment group.Meanwhile,the latter two groups were stratified according to the post operating observation periods(1h,3h,6h and 24h).Levels of blood serum creatinine(Scr) and the variation of ICAM-1 of polymorphonuclear neutrophils(PMNS) were tested in each group.Light microscope and immunohistochemical method were used to observe the histomorphology of nephridial tissue and the expression of NF-κB.Results showed that:(1)1h after reperfusion,levels of ICAM-1,NF-κB were increased and the score of renal tubular necrosis was significantly increased(P0.01) when compared with that of the sham-operated control one although the level of serum creatine(Scr) has no marked change(;2) 6h after reperfusion,the concentration of serum creatine in both IRI group and treatment one were significantly increased(P0.01).However,in LMWH treatment group,the levels of serum Cr,ICAM-1 and NF-κB were significantly decreased when" @default.
- W2376849610 created "2016-06-24" @default.
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- W2376849610 date "2007-01-01" @default.
- W2376849610 modified "2023-09-24" @default.
- W2376849610 title "Low Molecular Weight Heparin Therapy in Rat on Renal Ischemia Reperfusion Injury:Related to Expression of Nephridial Tissue Intercellular Adhesion Molecular-1 and NF-kappaB" @default.
- W2376849610 hasPublicationYear "2007" @default.
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