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- W2376858469 abstract "The effect of ammonia (ammonium chloride, NH.CDon the morphology of primary cultured astrocytes in vitro was studied preliminarily. The results showed that some injuries were early developed after ammonia administration, such as the edema of whole cell, a lot of vacuole formation in the cytoplasm and so on. Following that was the appear-ance of some basophilic minigranules in the cytoplasm. Even occasional karyopycnosis and debris resulted from the cell disintegration after higher concentration of ammonia administration(10mmol/L)for 72h. The wider intercellular space and obvious thickened astroid or branched cytoplasmic processes were observed after the long time of exposure to ammonia or large dose of ammonia. The results implicate the astrocytes express injuries and repair activities simul-taneously under hyperammonemia. Out of question, these morphological changes were the basis of the functional and metabolic abnormality of astrocytes, which may affect the neurons by the interaction between neuron and astrocyte fi-nally." @default.
- W2376858469 created "2016-06-24" @default.
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- W2376858469 date "1998-01-01" @default.
- W2376858469 modified "2023-09-22" @default.
- W2376858469 title "EFFECT OF AMMONIA ON THE MORPHOLOGY OF CULTURED ASTROCYTES" @default.
- W2376858469 hasPublicationYear "1998" @default.
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