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- W2376859097 abstract "Objective: To study the mRNA expression of activin A(ACT A)and follistatin(FS) at different stages in canine with cleft palate(CP) during periosteal distraction osteogenesis(PDO).Methods: Experimental CP models were established in 15 juvenile dogs by surgery.2 months after the surgery distraction device was placed under the periosteum at the edge of CP with a force of(2.45±0.20) N.Every 3 dogs were sacrificed 10,20,30,40 and 60 days respectively after the placement of distraction device,bone samples were harvested,RNA was extracted from the newly formed bone tissue of the distracted side and the control side respectively.ACT A and FS expressions were detected by RT-PCR.Results: A small amount of ACT A and FS mRNA were detected in the bone tissue samples of the control side from 10 to 60 days(P0.05).Higher expression of ACT A and FS mRNA was observed in the samples of the 10th day in the distracted side.ACT A mRNA increased by 1.78,2.82,4.27 and 3.04 times respectively 20,30,40 and 60 days after the fixation of the distraction device;FS mRNA increased by 1.52,2.12,2.47 and 1.90 times.Conclusion: ACT A and FS play important role in regulating osteogenesis in periosteum distraction." @default.
- W2376859097 created "2016-06-24" @default.
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- W2376859097 date "2012-01-01" @default.
- W2376859097 modified "2023-09-23" @default.
- W2376859097 title "Expression of activin A and follistatin in hard palate during periosteal distraction osteogenesis" @default.
- W2376859097 hasPublicationYear "2012" @default.
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