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- W2376862009 abstract "Objective: To investigate the protective effects and its mechanism of ligustrazine precondition on renal ischemia reperfusion injury in rats.Methods: 30 SD rats were divided into three groups randomly(n=10):sham operation group,ischemia reperfusion injury group(IR),and ligustrazine injection preconditioning group(LI).The model of renal ischemia reperfusion injury was produced,after renal ischemia lasting for 60 mins,then reperfusion for 24 hrs.The serum Scr and BUN levels were measured,the renal SOD and GSH_Px activities,MDA contents were detected respectively.Results: The contents of Scr(P0.01),BUN(P0.05),MDA(P0.05) were significantly lower,the activities of SOD(P0.01)and GSH_Px(P0.05) were significantly higher in ligustrazine injection preconditioning group(SFI) than that in ischemia reperfusion injury group.Conclusion: SOD and GSH_Px are important substabces of endogenous protection,and ligustrazine can enhance SOD and GSH_Px activities,and protect renal ischemia reperfusion injury." @default.
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- W2376862009 date "2006-01-01" @default.
- W2376862009 modified "2023-09-25" @default.
- W2376862009 title "Protective effects of ligustrazine on the renal ischemia reperfusion injury model in rats" @default.
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