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- W2376869868 abstract "In screening new hypocholesterolemic agents,eleven derivatives of estronewere examined in alimentary hyperlipemic rats.Of these,16,17-pyrazole es-trone(16,17-PES) was found to have cholesterol lowering action with weak es-trogenic activity.Subcutaneous or oral administration of 16,17-PES was shownto suppress the elevation of serum total Cholesterol,β-lipoprotein and α-lipo-protein cholesterol in the alimentary hyperlipmic rats.The efficacy of 16,17-PES was equivalent to that of esterone in male rats,but more potent than that ofestrone in female rats.Similar results were obtained when 16,17-PES was givenorally.In addition,the inhibitory effect of 16,17-PES on the body weight wasmuch weaker than that of estrone in male rats.No effect on alimentary hyper-lipemia and atherosclerosis in chickens were observed for 16,17-PES.The estro-genic(uterotrophic)activity of 16,17-PES given orally or intramuscularly wasequivalent to 1/3 or 1/15 of that of estrone in the immature rats.No significanttoxic effect was found when 16,17-PES(0.1—0.2mg/kg)was given intramuscu-larly to rats and dogs once a day for 2 months." @default.
- W2376869868 created "2016-06-24" @default.
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- W2376869868 date "1983-01-01" @default.
- W2376869868 modified "2023-09-23" @default.
- W2376869868 title "EFFECT OF 16,17-PYRAZOLE ESTRONE ON ALIMENTARY HYPERLIPEMIA AND ATHEROSCLEROSIS IN RATS AND CHICKENS" @default.
- W2376869868 hasPublicationYear "1983" @default.
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