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- W2376870923 abstract "OBJECTIVE To investigate the hypoglycemic effect and mechanism of polysaccharides in Ramulus Mori(PRM) on diabetes model mouse.METHODS The mice were ip given streptozotocin 100 mg·kg-1 combined with high fat diet to prepare the diabetic mouse model.The diabetic mice were ig given PRM 200,400 and 600 mg·kg-1 once daily for 4 weeks.Blood-glucose level was measured by glucose oxidase method,serum superoxide dismutase(SOD) activity and malondialdehyde(MDA) content were detected with spectrophotometric method.The hepatic glycogen,serum triglycerides(TG),serum total cholesterols(TCH) and serum insulin level were measured with colorimetric method,glycerophosphoric acid oxidase method,enzymatic-trinder method and ELISA,respectively.RESULTS The blood-glucose level of the diabetic mice were decreased 33.3% and 29.9%(P0.05) in PRM 400 and 600 mg·kg-1 groups compared with that before giving PRM.Compared with that of model group,PRM 200,400 and 600 mg·kg-1 decreased 34.6%(P0.05),40.4% and 38.8%(P0.01).PRM could also significantly decrease the content of MDA,TG and TCH(P0.05),and significantly increase the SOD activity(P0.01),hepatic glycogen content(P0.05),serum insulin level and insulin sensitivity(P0.05).CONCLUSION PRM has hypoglycemic effect on diabetic mice.This action may be related with its scavenging harmful free radicals,inhibiting lipid peroxidation,regulating lipids metabolism,increasing the storage content of hepatic glycogen and improving insulin secretion and insulin sensitivity." @default.
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- W2376870923 date "2012-01-01" @default.
- W2376870923 modified "2023-09-26" @default.
- W2376870923 title "Hypoglycemic effect of polysaccharides in Ramulus Mori on diabetic model mice" @default.
- W2376870923 hasPublicationYear "2012" @default.
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