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- W2376872004 abstract "OBJECTIVE:To evaluate the expression of survivin in nasopharyngeal carcinoma (NPC) and the relationship between the expression and the clinical characteristics and its prognostic value. METHODS: Expression of survivin was investigated by using the immunohistochemical staining method in 92 cases of NPC. Life table, Kaplan-Meier analysis and Cox regression analysis were used in discussing the prognosis. RESULTS: The average positive rates of survivin in NPC was (37.24±30.94) %. Tumors were scored high expression level when 25% cancer cells stained positive, thus the high expression of survivin was 56.52%(52/92). There were no significant correlations between survivin and age, sex, primary tumor size, local-regional relapse and distant metastasis, but high lymph-node metastasis rate was seen in the high expression group of survivin. When analyzed for prognostic significance, patients with low survivin expression had better overall survival than the group with high survivin expression (87.21% vs 52.28%, P=0.004). Cox regression analysis confirmed that high survivin expression was related to worse prognostic in NPC patients. CONCLUSIONS: There is high expression level of survivin in NPC, which may play an important role in the oncogenesis and tumor development. Over expression of survivin is related to poor prognosis of NPC patients. The determination of survivin expression may provide predictive information on NPC patients." @default.
- W2376872004 created "2016-06-24" @default.
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- W2376872004 date "2006-01-01" @default.
- W2376872004 modified "2023-09-23" @default.
- W2376872004 title "Expression of survivin in nasopharyngeal carcinoma and its prognostic significance" @default.
- W2376872004 hasPublicationYear "2006" @default.
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