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- W2376876105 abstract "Objective To investigate the cytotoxicity of EGFR /CD3 bispecific antibody by chemical synthesis against pancreatic cancer cells in vitro. Methods In previous researches,the EGFR / CD3 bispecific antibody w as prepared by chemical synthesis. The cytotoxicity activity of this antibody against pancreatic cancer w as analyzed by the cell combination rate assay and51Cr assay. The cell cycle and apoptosis w ere analyzed by flow cytometry. Then the comparisions of the cytotoxicity activity betw een the bispecific antibody and EGFR mAb w as conducted. Results The biding rate of EGFR / CD3 bispecific antibody cell w ith effector cells PBLS and pancreatic cancer cell line SW1990 w as high enough to satisfy the treatment demand. The lysis rate and apoptosis rate of cancer cells treated w ith immunological effector cells targeted by EGFR / CD3 bispecific antibody w ere higher than those of the control groups significantly( P 0. 05). The apoptosis rate of cancer cells increased. Conclusion It is suggested that the cytotoxicity of effector cells could be enhanced by EGFR / CD3 bispecific antibody in vitro,so it has promising curative effect on pancreatic cancer." @default.
- W2376876105 created "2016-06-24" @default.
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- W2376876105 date "2014-01-01" @default.
- W2376876105 modified "2023-09-24" @default.
- W2376876105 title "Experimental study of anti-CD3 / anti-EGFR bispecific antibody therapeutic activity against pancreatic cancer cells" @default.
- W2376876105 hasPublicationYear "2014" @default.
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