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- W2376881537 abstract "Objective: To investigate the effect of simvastatin on the expression of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) and its mechanisms in mouse viral myocarditis VMC caused by coxsackievirus B3(CVB3). Methods: Sixty male BALB/C mice aged four weeks were involved and divided into five groups randomly and equally as normal control group, viral control group, oral administration of simvastatin 1 mg/kg group, 10 mg/kg group, and 100 mg/kg group, and the last four groups were inoculated intraperitoneally with 0.2 ml of CVB3(Nancy strain). Normal control mice were inoculated intrapritonealy with 0.2 ml of Eagle's solution. Viral control group and normal control group were administrated with starch solution everyday. All mice were sacrificed at 7th day. Histological cross sections of hearts were stained with hematoxylin-eosin and myocardial histopathologic scores were counted under optical microscope. Viral titer was determined according to plaque-counting technique. The levels of TNF-α in myocardial tissue and serum IL-6 were assayed by immunohistochemical stain and ELISA respectively.Results: ① The grade of myocardial necrosis in 100 mg/kg group and 10 mg/kg group was significantly lower than in viral control group(P0.05 respectively). There were no significant differences between the 1 mg/kg group and viral control group (P0.05). ② The levels of viral titers, IL-6 and TNF-α in 100 mg/kg group and 10 mg/kg group were significantly lower than in viral control group(P0.01 and P0.05 respectively), and there were the same result in 100 mg/kg group compared with 10 mg/kg group (P0.05). The level of IL-6 and TNF-α in normal group was lower than in viral control group(P0.01), and lower than in 10 mg/kg group and 100 mg/kg group also (both P0.05). ③There was no significant difference in heart/body weight ratio among the five groups. Conclusion: Simvastatin could reduce the myocardial necrosis in VMC mice infected by CVB3 in acute period and this function positively correlated with the dose of simvastatin. The properties of anti-inflammatory of simvastatin may play a key role in this process. The anti-viral effect in VMC mice would decrease after administration of simvastatin, but this result wouldn't deteriorate the VMC in the acute period." @default.
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- W2376881537 date "2007-01-01" @default.
- W2376881537 modified "2023-09-25" @default.
- W2376881537 title "Simvastatin’s Protective Effect and Its Mechanism in Acute Period of Viral Myocarditis Caused by CVB3 in Mice" @default.
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