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- W2376883525 abstract "The allergens Ara h2 and Ara h6 are the most clinically relevant allergens of peanut allergies.Ara h2 can completely inhibit the IgE binding ability of Ara h6 while Ara h6 can only partially inhibit IgE epitope of Ara h2.Comparison between the primary and tertiary structures of Ara h2 and Ara h6 is carried out for the exploration of this mechanism.Ara h2 contains a unique fragment(from 60 to 73) which includes two of the three major linear IgE epitopes of Ara h2.A 3-D structure of Ara h2 is obtained by homology modeling with Ara h6 as the template.When the structure of Ara h2 and Ara h6 are superposed,an extra outstretched anti-parallel β-sheet linked a loop(from 58 to 72) is found within the structure of Ara h2.It also contains the sequence encoding the above-mentioned two IgE epitopes.This study gives a explanation for the difference of Ara h2 and Ara h6 by comparison of primary and tertiary structures of Ara h2 and Ara h6.The explanation lays down the foundation for understanding of the mechanisms of peanut allergies and future development of hypoallergic vaccines." @default.
- W2376883525 created "2016-06-24" @default.
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- W2376883525 date "2010-01-01" @default.
- W2376883525 modified "2023-09-23" @default.
- W2376883525 title "Bioinformatics comparison of peanut allergen Ara h2 and Ara h6" @default.
- W2376883525 hasPublicationYear "2010" @default.
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