SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2376889944> ?p ?o ?g. }

Showing items 1 to 77 of 77 with 100 items per page.

W2376889944 abstract "Objective Polyinosinic polycytidylic acid(PolyI:C)was used to generate primary biliary cirrhosis animal model in C57BL/6 mice,and CD4o ligand in T lymphocytes was analyzed to show T cell activation.Methods 20 C57BL/6 mice were divided into 2 groups equally,model group and control group.Mice in model group were injected with PolyI:C(5 mg/kg)and PBS twice a week.120 days after injection they were put to death.Antimitochondrial antibodies(AMA)were detected by indirect immunofluorescence(IIFL),pathology changes were determined by haematoxylin and eosin stain(HE), alkali phosphatase(ALP)was assayed by biochemistry analysator,at last the number of CD_4~+T,CD_8~+T cells and the CD_(40)L expression in T cells were analyzed by flow cytometry(FCM).Results After 120 days PolyI:C injection all mouse in model group were found AMA positive and inflammation cell infiltration around bile ducts.However,there were almost no changes in serology and pathology items in control group.In addition,the level of ALP in model group was higher than that in control group(P0.001).The ratios of CD_~(40)L~+/CD_4~+,CD_(40)L~+/CD_8~+T cells in model group[(4.35±0.34)%,(1.42±0.10)%]were significantly higher than that in control group[(0.78±0.10)%,(0.43±0.04)%,P0.01] respectively,but the percentage of CD_4~+and CD_8~+over total T cells in model group[(25.83±1.80)%, (24.84±2.70)%]had no significant difference from that in control group[(20.51±3.46)%,(17.84± 1.53)%,P0.05].Conelusions Primary biliary cirrhosis animal model can be established by injecting PolyI:C in C57BL/6 mouse and activated CD_4~+and CD_8~+T cells are critical in PBC." @default.
W2376889944 created "2016-06-24" @default.
W2376889944 creator A5029031096 @default.
W2376889944 date "2007-01-01" @default.
W2376889944 modified "2023-09-26" @default.
W2376889944 title "Development of primary biliary cirrhosis animal model and the analysis of CD_(40)L expression on T cells in peripheral blood" @default.
W2376889944 hasPublicationYear "2007" @default.
W2376889944 type Work @default.
W2376889944 sameAs 2376889944 @default.
W2376889944 citedByCount "0" @default.
W2376889944 crossrefType "journal-article" @default.
W2376889944 hasAuthorship W2376889944A5029031096 @default.
W2376889944 hasConcept C125473707 @default.
W2376889944 hasConcept C126322002 @default.
W2376889944 hasConcept C134018914 @default.
W2376889944 hasConcept C142724271 @default.
W2376889944 hasConcept C153911025 @default.
W2376889944 hasConcept C159654299 @default.
W2376889944 hasConcept C160160445 @default.
W2376889944 hasConcept C16685009 @default.
W2376889944 hasConcept C181199279 @default.
W2376889944 hasConcept C185592680 @default.
W2376889944 hasConcept C203014093 @default.
W2376889944 hasConcept C204232928 @default.
W2376889944 hasConcept C2776919888 @default.
W2376889944 hasConcept C2778236600 @default.
W2376889944 hasConcept C2780366471 @default.
W2376889944 hasConcept C553184892 @default.
W2376889944 hasConcept C55493867 @default.
W2376889944 hasConcept C71924100 @default.
W2376889944 hasConcept C86803240 @default.
W2376889944 hasConceptScore W2376889944C125473707 @default.
W2376889944 hasConceptScore W2376889944C126322002 @default.
W2376889944 hasConceptScore W2376889944C134018914 @default.
W2376889944 hasConceptScore W2376889944C142724271 @default.
W2376889944 hasConceptScore W2376889944C153911025 @default.
W2376889944 hasConceptScore W2376889944C159654299 @default.
W2376889944 hasConceptScore W2376889944C160160445 @default.
W2376889944 hasConceptScore W2376889944C16685009 @default.
W2376889944 hasConceptScore W2376889944C181199279 @default.
W2376889944 hasConceptScore W2376889944C185592680 @default.
W2376889944 hasConceptScore W2376889944C203014093 @default.
W2376889944 hasConceptScore W2376889944C204232928 @default.
W2376889944 hasConceptScore W2376889944C2776919888 @default.
W2376889944 hasConceptScore W2376889944C2778236600 @default.
W2376889944 hasConceptScore W2376889944C2780366471 @default.
W2376889944 hasConceptScore W2376889944C553184892 @default.
W2376889944 hasConceptScore W2376889944C55493867 @default.
W2376889944 hasConceptScore W2376889944C71924100 @default.
W2376889944 hasConceptScore W2376889944C86803240 @default.
W2376889944 hasLocation W23768899441 @default.
W2376889944 hasOpenAccess W2376889944 @default.
W2376889944 hasPrimaryLocation W23768899441 @default.
W2376889944 hasRelatedWork W135626770 @default.
W2376889944 hasRelatedWork W1571673987 @default.
W2376889944 hasRelatedWork W1578540050 @default.
W2376889944 hasRelatedWork W2347479661 @default.
W2376889944 hasRelatedWork W2349979936 @default.
W2376889944 hasRelatedWork W2353795371 @default.
W2376889944 hasRelatedWork W2357492025 @default.
W2376889944 hasRelatedWork W2358988440 @default.
W2376889944 hasRelatedWork W2360862003 @default.
W2376889944 hasRelatedWork W2360880475 @default.
W2376889944 hasRelatedWork W2364530184 @default.
W2376889944 hasRelatedWork W2369762924 @default.
W2376889944 hasRelatedWork W2376806954 @default.
W2376889944 hasRelatedWork W2377103530 @default.
W2376889944 hasRelatedWork W2380310072 @default.
W2376889944 hasRelatedWork W2418035737 @default.
W2376889944 hasRelatedWork W2775874336 @default.
W2376889944 hasRelatedWork W3024521831 @default.
W2376889944 hasRelatedWork W3028652550 @default.
W2376889944 hasRelatedWork W3031024668 @default.
W2376889944 isParatext "false" @default.
W2376889944 isRetracted "false" @default.
W2376889944 magId "2376889944" @default.
W2376889944 workType "article" @default.