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- W2376891903 abstract "In order to determine whether Artestinate(ART) and Oxymatrine(MOX) could reverse the immunosuppressive effect of mouse colon-rectal carcinoma cell line Colon26,recultured supernatants of the Colon26 cell line cultures were collected after treated with either ART or MOX respectively,with the corresponding supernatants without treatment of any herbs as control.The effects of different supernatants on the immune functions of mouse splenocytes including the killing activity of NK cells and ConA induced transformation,detected by MTT assay,the expressions of CD4+and CD8+ cells assayed by flow cytometry and the levels of 5 immunosuppressive agents,such as TGF-β1,VEGF,IL-4,IL-6 and IL-10 determined by quantitative ELISA,were investigated accordingly.Meanwhile,the relationship between the down-regulating effects of ART and MOX on the Colon26 cell line to secrte immunosuppressive molecules and create immunosuppression was evaluated.It was demonstrated that the 5 immunosuppressive agents all could be detected in the supernatants of the Colon26 cell cultures without treatment of any herbs with highest level of TGF-β1.The immune functions of mouse splenocytes were remarkebly inhibited by the supernatants of Colon26 cell cultures.In case of the Colon26 cell cultures treated with ART,the levels of TGF-β1,VEGF and IL-10 in the first recultured supernatants and its inhibition of immune function except the expressions of CD4+and CD8+cells were greatly decreased;and the levels of TGF-β1 and IL-10 in the second recultured supernatants remained decreasing,and its inhibition on the ConA induced transformation as well as the expressions of CD4+ CD8-cells still kept decreasing.In case of the Colon26 cells treated with MOX,the levels of TGF-β1 and IL-10 in the first recultured supernatants and its inhibition of transformation also decreased greatly,while the levels of TGF-β1 and IL-10 in the second recultured supernantants kept decresing,and its inhibition of transformation increased was just the same as control.The positive correlations existed between the level of TGF-β1 and inhibition of transformation after treatment with ART and MOX,as well as between level of IL-10 and inhibition of NK killing after treatment with ART alone.It is concluded that the results in the present study demonstrate the reversing effect of the immunosuppression induced by the Colon26 cells through the decrease of the secreted immunosuppressors,and this effect may be the new antitumor mechanism afforded by ART and MOX." @default.
- W2376891903 created "2016-06-24" @default.
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- W2376891903 date "2006-01-01" @default.
- W2376891903 modified "2023-09-23" @default.
- W2376891903 title "Influence of Artesunate and Oxymatrine on the immunosuppressive effect of mouse colon-rectal carcinoma cell line Colon 26" @default.
- W2376891903 hasPublicationYear "2006" @default.
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