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- W2376892127 abstract "Objective:To investigate the effects of clonidine treatment on the reward and analgesia of subsequent morphine in rats.Methods:Morphine dependence of rats was established by dose-increasing administration(5-40 mg·kg-1,3 times·d-1,for 30 d).During the initial 7 d of withdrawal,rats were treated with clonidine(0.1 mg·kg-1,3 times·d-1)or saline.Then rats were trained for morphine(1 mg·kg-1)conditioned place preference(CPP).The acquisition and retention of CPP were monitored.Analgesia of morphine(5 mg·kg-1)in rats was assayed with tail-flick protocol after CPP training.Results:After 4 d training,clonindine-treated rats developed significant CPP,but non-treated rats did not.After 8 d training,both clonidine-treated and non-treated rats acquired significant CPP.After 14 d of training cessation,CPP of clonidine-treated rats extinguished,while CPP of clonidine non-treated rats still existed.Clonidine-treated rats and non-treated rats showed no significant difference in tail-flick test.Conclusion:Clonidine treatment during withdrawal affects the rewarding effects,but not the analgesia tolerance,to subsequent morphine exposure in morphine-dependent rats." @default.
- W2376892127 created "2016-06-24" @default.
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- W2376892127 date "2008-01-01" @default.
- W2376892127 modified "2023-09-25" @default.
- W2376892127 title "EFFECTS OF CLONIDINE TREATMENT DURING WITHDRAWAL ON CONDITIONED PLACE PREFERENCE AND ANALGESIA OF SUBSEQUENT MORPHINE IN RATS" @default.
- W2376892127 hasPublicationYear "2008" @default.
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