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- W2376917457 abstract "AIM To further investigate the anti-inflammatory mechanisms of pioglitazone, the mRNA expressions of S100A8 and S100A9 in synovium and peritoneal macrophages of gouty arthritis or peritonitis rats induced by monosodium urate (MSU) monohydrate crystal were observed. METHODS Acute gouty arthritis or peritonitis was induced with once injection of MSU into rat ankle joint cavity or peritoneal cavity, respectively. Rats were treated with pioglitazone (20 mg·kg-1·d-1, ig) for 5 d, beginning on 3 d before MSU injection. On the day of model induction, MSU was injected 2h after pioglitazone administration. The mRNA expressions of S100A8 and S100A9 in rat synovium at 48 h and macrophages from peritoneal cavity at 4, 8, 24, 48 and 72 h after MSU injection were determined by reverse transcription polymerase chain reaction (RT-PCR). RESULTS In normal rats, very low levels of S100A8 mRNA and S100A9 mRNA (0.01±0.01, 0.20±0.07) in synovium and even none of them in peritoneal macrophages could be detected. In gouty arthritic rats, however, higher levels of them (1.21±0.20, 1.44±0.20) were detected at 48 h after MSU injection, and pioglitazone treatment could attenuate the levels (0.26±0.14, 0.25±0.16). In rats with peritonitis, the mRNA expressions of S100A8 and S100A9 in peritoneal macrophages were markedly increased at 4, 8, 24, 48 and 72 h after MSU injection, and the expressions at 48 h (S100A8 mRNA: 1.17±0.38 vs 0.03±0.02; S100A9 mRNA: 0.90±0.31 vs 0.10±0.01) and 72 h (0.70±0.20 vs 0.02±0.01; 0.77±0.10 vs 0.02±0.01) were down-regulated by pioglitazone administration. CONCLUSION Pioglitazone can ameliorate MSU-induced inflammations. The mechanisms may be related to its inhibitory effect on mRNA expressions of S100A8 and S100A9." @default.
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- W2376917457 date "2007-01-01" @default.
- W2376917457 modified "2023-09-25" @default.
- W2376917457 title "Effects of pioglitazone on mRNA expressions of S100A8 and S100A9 in monosodium urate monohydrate crystal induced inflammations" @default.
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