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- W2376928618 abstract "Objective To investigate the expressions of signal transducers and activators of transcription 3(STAT3),vascular endothelial growth factor(VEGF) and microvessel density(MVD) in adrenal cortical carcinoma(ACC) and to discuss their clinical significance.Methods 37 adrenal cortical neoplasm specimens were divided into two groups,20 in the benign group and 17 in the malignant group(adrenal cortical carcinoma,ACC group).The expressions of STAT3,VEGF and MVD were detected with immunohistochemical staining.Results STAT3 was highly expressed in the ACC group(11/17,64.71%),while lowly expressed in the benign group(4/20,20.00%),with significant difference(P0.05).VEGF staining was seen in 70.59%(12/17) of the malignant cases versus 25.00%(5/20) of the benign cases,with significant difference(P0.01).MVD was highly expressed in the ACC group than in the benign group(76.40±15.64 vs.21.05±8.07),with significant difference(P0.05).In both benign and malignant adrenal neoplasm,STAT3 expression was positively correlated with VEGF expression,which was positively correlated with MVD.Conclusion The high expression of STAT3 and VEGF in ACC contributes to tumor angiogenesis." @default.
- W2376928618 created "2016-06-24" @default.
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- W2376928618 date "2012-01-01" @default.
- W2376928618 modified "2023-09-23" @default.
- W2376928618 title "Expressions of STAT 3,VEGF and MVD and the significance in adrenal cortical carcinoma" @default.
- W2376928618 hasPublicationYear "2012" @default.
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