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- W2376928971 abstract "Objective:To investigate the pathogenesis-related immunological mechanisms of T cell subsets in aplastic anemia by dectecting ratio of T cell subsets and the level of cytokines secreted by Treg cells.Methods:Basing on clinical diagnostic criteria,the peripheral blood samples of aplastic anemia were gathered from the initial issuance,the hematopoietic recovery and normal controls.The proportion of CD4+,CD8+,NK,NKT,Treg cells were counted by FACS respectively.The Treg cells of samples were separated by immunomagnetic beads and observed by stimulating factors.The supernatants were then collected after 24 or 48 hours.Enzyme-linked immunosorbent assay(ELISA) was applied to examine the expression of IL-10,IL-35 and TGF-β secreted by Treg cells.Results:The proportion of CD4+,Treg cells in the initial issuance was the lowest among the groups.The result was statistically significant(P0.05) that the proportion of CD8+ T cells was significantly higher in patients with aplastic anemia.There was no statistical difference in NK,NKT cells between aplastic anemia and normal controls(P0.05).The culture supernatant in ELISA showed that the expression of IL-10,IL-35 and TGF-β was significantly lower(P0.05) in the initial cases compared to the normal controls.Conlusion: Dysimmunity of T cells is a significant link in the aplastic anemia pathogenesis.Treg cells may play a positive regulatory role in the process of hematopoietic function recovery of aplastic anemia patients." @default.
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- W2376928971 date "2012-01-01" @default.
- W2376928971 modified "2023-09-25" @default.
- W2376928971 title "The significance of regulatory T cells and cytokines secreted by regulatory T cells in aplastic anemia" @default.
- W2376928971 hasPublicationYear "2012" @default.
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