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- W2376939397 abstract "Objective To compare the efficacy of dexmedtomidine combined with low-dose of midazolam and midazolam only for sedation during slow induction of anesthesia.Methods 40 patients scheduled for nonemergency surgery with slow induction of anesthesia were randomized into two groups.MDZ group received midazlolam 0.05 mg/kg,iv.with additional doses to achieve OAA/S 2~4;DEX-MDZ group received midazolam 0.02 mg/kg followed by dexmedetomidine 1 μg/kg,then an infusion of dexmedetomidine 0.1 μg/(kg · h) and pumped to 0.7 μg/(kg · h)to achieve OAA/S 2~4.The BP,HR,OAA/S score and reaction at important time points were recorded;The memory and satisfactory degree of slow induction of anesthesia were also recorded.Results There was no significant difference in BP and HR between the two groups.Patients in DEX-MDZ group were calmed and operated more significantly during the procedure with fewer adverse reactions than those of MDZ group.The DEX-MDZ group was more satisfactory in slow induction of anesthesia than MDZ group(P0.001).Conclusion Dexmedetomidine combined with low dose of midazolam is more effective than midazolam only for sedation during slow induction of anesthesia." @default.
- W2376939397 created "2016-06-24" @default.
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- W2376939397 date "2013-01-01" @default.
- W2376939397 modified "2023-09-23" @default.
- W2376939397 title "Effects of dexmedetomidine combined with low-dose of midazolam for sedation on slow induction of anesthesia" @default.
- W2376939397 hasPublicationYear "2013" @default.
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