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- W2376945315 abstract "Objective The possible mechanisms of protective effects of calcium and zinc on learning and memory disorders from low level lead exposure were investigated. Methods The pups were given drinking water containting 100 mg/L lead from day 12 of gestation to 40 after birth, and separately given normal AIN|76 TM diet, +Ca AIN|76 TM diet (1 25%) and +Zn AIN|76 TM diet (100 mg/kg). Results Blood and brain lead concentrations of pups fed +Ca diet (0 29 μmol/L,0 62 μg/g) and blood lead concentrations of pups fed +Zn diet (3 05 μg/g) were all significantly lower than those of pups fed normal diet. Nictric oxide (NO) mean contents of both pups fed +Ca (27 68 μmol/g protein) and+Zn diet (13 82 μmol/g protein) were significantly higher than those of pups fed normal diet ( P 0 05) Protein kinase C (PKC) activities of both pups fed+Ca[0 33 pmol/(min·μg protein)] and +Zn diet [0 38 pmol/(min·μg protein)] were significantly lower than that of pups fed normal diet ( P 0 05).Conclusion These results indicate that the possible mechanisms of protective effects of calcium and zinc on learning and memory disorders from low level lead exposure are decrease on lead accumulation, hippocampus PKC and increase in hippocampus and cerebellum NO content." @default.
- W2376945315 created "2016-06-24" @default.
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- W2376945315 date "2002-01-01" @default.
- W2376945315 modified "2023-09-25" @default.
- W2376945315 title "Study on mechanisms of protective effects of calcium and zinc on memory disorders from lead exposure" @default.
- W2376945315 hasPublicationYear "2002" @default.
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